Reducing atherogenic cholesterol levels can significantly reduce the risk for atherosclerotic cardiovascular disease (ASCVD). There is strong evidence supporting aggressive use of statins in primary prevention of ASCVD.

a) List the major risk factors for ASCVD and lifestyle modifications to reduce cholesterol levels (4 marks)

b) Discuss concisely the main underlying principles for aggressive use of statins in primary prevention of ASCVD and the safety of statins. (8 marks)

c) What are the alternatives to statin or add-on drugs? (3 marks)