A patient weight 45 kg received vancomycin 900 mg IV Q8H for MRSA pneumonia. The drug was infused over 60 min. Trough concentration measured after the 3rd dose was 22 mcg/ml. (Vd = 0.4L/kg)
i) What is the half life of elimination? (3 marks)
ii) How long will it take the trough level to reach 18 mcg/ml (2marks)