S.W. is a 80-year-old male patient diagnosed with active pulmonary tuberculosis (“TB”) in February 2021. His past medical history includes benign prostatic hyperplasia and hypertension. S.W. is prescribed with the traditional anti-TB regimen. 

a) Please describe what pharmacological agents are included in the traditional first line regimen for TB and the important baseline examinations before initiating the drug treatment. (8 marks) 

b) 2 weeks after starting the traditional regimen, S.W. is admitted to hospital due to his increased aspartate transaminase (“AST”; 20x upper limit of normal (“ULN”)) and bilirubin (> 3 mg/dL). Please discuss the acute management plan for this patient. (4 marks) 

c) 2 months later, the physician decides to prescribe streptomycin 15 mg/kg IM once daily to S.W.'s anti-TB regimen. What important counselling points should be provided to the patient? (3 marks)